What Are GLP-1 Medications?
GLP-1 (glucagon-like peptide-1) medications are a class of drugs that mimic a hormone your body naturally produces after eating.
This hormone helps regulate blood sugar and signals feelings of fullness. Common GLP-1 medications include semaglutide and tirzepatide (which combines GLP-1 with another hormone called GIP).
How They Work
Slow digestion — helping you feel full longer
Reduce appetite — quieting "food noise" and constant thoughts about eating
Support insulin release — when blood sugar rises
Moderate glucose output — helping prevent excess liver glucose release
Who May Benefit
GLP-1 medications may be appropriate if you struggle with weight management despite lifestyle efforts, have metabolic concerns like prediabetes, experience persistent cravings, or need support managing blood sugar.
Your physician will review your full medical history, current medications, and goals before making any recommendations.
What to Expect
Most patients start at a low dose that gradually increases over several weeks. This helps your body adjust and minimizes side effects.
Reduced appetite
Often noticed within the first few weeks
Gradual weight loss
Typically 1–2 pounds per week at full dose
Possible mild nausea
Especially when starting or increasing dose
Digestive changes
Bowel patterns may shift as your body adjusts
What the Research Shows
~15%
Average weight loss with semaglutide over 68 weeks in clinical trials
15–21%
Average weight loss with tirzepatide, depending on dose
Individual results vary. Your physician will monitor your progress and adjust treatment as needed.
Important Safety Information
GLP-1 medications are not appropriate for everyone, especially those with personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal disease.
Your care team will monitor you throughout treatment and review any contraindications before prescribing.